Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
alpha-thrombin | - |
Homo sapiens |
fibrinogenase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | thrombin down-regulates the transforming growth factor-beta-mediated synthesis of collagen and fibronectin by human proximal tubule epithelial cells through the endothelial protein C receptor-dependent activation of protease-activated receptor-1. The activation of protease-activated receptor-1 by thrombin inhibits the tumor necrosis factor -alpha-mediated synthesis of interleukin-6 and interleukin-8 and downregulates the transforming growth factor -beta-mediated expression of extracellular matrix proteins | Homo sapiens |