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Literature summary for 3.4.21.5 extracted from
- Thrombin down-regulates the TGF-beta-mediated synthesis of collagen and fibronectin by human proximal tubule epithelial cells through the EPCR-dependent activation of PAR-1 (2010), J. Cell. Physiol., 225, 233-239.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha-thrombin | - |
Homo sapiens |
| fibrinogenase | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | thrombin down-regulates the transforming growth factor-beta-mediated synthesis of collagen and fibronectin by human proximal tubule epithelial cells through the endothelial protein C receptor-dependent activation of protease-activated receptor-1. The activation of protease-activated receptor-1 by thrombin inhibits the tumor necrosis factor -alpha-mediated synthesis of interleukin-6 and interleukin-8 and downregulates the transforming growth factor -beta-mediated expression of extracellular matrix proteins | Homo sapiens |
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Release 2023.1 (January 2023)
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