Literature summary for 3.4.21.5 extracted from

Chen, H.T.; Tsou, H.K.; Tsai, C.H.; Kuo, C.C.; Chiang, Y.K.; Chang, C.H.; Fong, Y.C.; Tang, C.H.
Thrombin enhanced migration and MMPs expression of human chondrosarcoma cells involves PAR receptor signaling pathway (2010), J. Cell. Physiol., 223, 737-745.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
fibrinogen + H2O	Homo sapiens	-	fibrin + fibrinopeptide A + fibrinopeptide B	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
fibrinogen + H2O	-	Homo sapiens	fibrin + fibrinopeptide A + fibrinopeptide B	-	?

General Information

General Information	Comment	Organism
physiological function	thrombin enhances the migration of chondrosarcoma cells by increasing matrix metalloproteinase-2 and matrix metalloproteinase-13 expression through the protease-activated receptor/phospholipase C/protein kinase Calpha/c-Src/nuclear factor-kappaB signal transduction pathway	Homo sapiens

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Release 2023.1 (January 2023)