Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
fibrinogen + H2O | Homo sapiens | - |
fibrin + fibrinopeptide A + fibrinopeptide B | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fibrinogen + H2O | - |
Homo sapiens | fibrin + fibrinopeptide A + fibrinopeptide B | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | in thrombin- and collagen-stimulated platelets, protein kinase A is activated by cAMP-independent mechanisms involving dissociation of the catalytic subunit of protein kinase A from an nuclear factor kappaB-IkappaBalpha-catalytic subunit of protein kinase complex. Thrombin and collagen cause platelet activation and fine-tune this response by initiating downstream nuclear factor kappaB-dependent protein kinase A catalytic subunit activation, as a novel feedback inhibitory signaling mechanism for preventing undesired platelet activation | Homo sapiens |