Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | thrombin-mediated expression of interleukin-6 and CXCL8 is significantly inhibited by LY294002, AKT IV, RO318220, and GF109203X as well as by diphenyleneiodium at the messenger RNA and the protein levels. SB202129 and U0126 also significantly attenuate thrombin-mediated release of interleukin-6 and CXCL8 proteins from human aortic smooth muscle cell | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | thrombin elevates transcripts for interleukin-6, CXCL8, and CCL11 genes and also enhances release of interleukin-6 and CXCL8 protein from human aortic smooth muscle cell, thrombin promotes proinflammatory phenotype in human vascular smooth muscle cell | Homo sapiens |