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Literature summary for 3.4.21.5 extracted from

  • Bogatkevich, G.S.; Ludwicka-Bradley, A.; Silver, R.M.
    Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts (2009), Arthritis Rheum., 60, 3455-3464.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.5

Inhibitors

Inhibitors Comment Organism Structure
dabigatran i.e. N-[2-(4-amidinophenylaminomethyl)-1-methyl-1H-benzimidazol-5-ylcarbonyl]-N-(2-pyridinyl)-beta-alanine, direct thrombin inhibitor, dabigatran inhibits thrombin-induced cell proliferation at concentrations of 50-1000 ng/ml Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens
-
 fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen + H2O
-
 Homo sapiens fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?

General Information

General Information Comment Organism
physiological function thrombin activates protease-activated receptor 1 and induces a myofibroblast phenotype in normal lung fibroblasts resembling the phenotype of scleroderma lung myofibroblasts Homo sapiens