Application | Comment | Organism |
---|---|---|
medicine | rabbits receiving infusions with recombinant hirudin containing the RGD motif, which competitively inhibits the binding of fibrinogen to GP IIb/IIIa on platelets, have prolonged thrombin time, prothrombin time. and activated partial thromboplastin time which are similar to that of wild-type hirudin. In addition, recombinant RGD-hirudin is capable of inhibiting platelet aggregation and is two to three times more effective than wild-type hirudin in preventing thrombosis | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Hirudin | - |
Oryctolagus cuniculus | |
RGD-hirudin | recombinant hirudin containing the RGD motif which competitively inhibits the binding of fibrinogen to GP IIb/IIIa on platelets. Specific anti-thrombin activity of RGD-hirudin is 12000 ATU/mg and equivalent to native hirudin, and it addiotionally inhibits platelet aggregation | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
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