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Literature summary for 3.4.21.5 extracted from

  • Huang, Y.L.; Shi, G.Y.; Lee, H.; Jiang, M.J.; Huang, B.M.; Wu, H.L.; Yang, H.Y.
    Thrombin induces nestin expression via the transactivation of EGFR signalings in rat vascular smooth muscle cells (2009), Cell. Signal., 21, 954-968.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus nestin gene expression is regulated by the thrombin-mediated transactivation of EGFR in serum-deprived primary cultures of vascular smooth muscle cells. Upon binding of thrombin, regulator PAR-1 induces c-Src resulting in direct intracellular phosphorylation of EGFR and in the extracellular activation of the matrix metalloprotease MMP-2-mediated shedding of HB-epidermal growth factor ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 commercial product
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information nestin gene expression is regulated by the thrombin-mediated transactivation of EGFR in serum-deprived primary cultures of vascular smooth muscle cells. Upon binding of thrombin, regulator PAR-1 induces c-Src resulting in direct intracellular phosphorylation of EGFR and in the extracellular activation of the matrix metalloprotease MMP-2-mediated shedding of HB-epidermal growth factor Rattus norvegicus ?
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