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Literature summary for 3.4.21.5 extracted from

  • Choi, M.S.; Kim, Y.E.; Lee, W.J.; Choi, J.W.; Park, G.H.; Kim, S.D.; Jeon, S.J.; Go, H.S.; Shin, S.M.; Kim, W.K.; Shin, C.Y.; Ko, K.H.
    Activation of protease-activated receptor1 mediates induction of matrix metalloproteinase-9 by thrombin in rat primary astrocytes (2008), Brain Res. Bull., 76, 368-375.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the presence of thrombin induces a significant increase in matrix metalloprotease-9 activity and also increases its mRNA expression in primary astrocytes. Thrombin-induced matrix metalloprotease-9 production is inhibited by the selective inhibitor of protease-activated receptor PAR-1, SCH 79797 and by PDS98059 ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 commercial product
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Source Tissue

Source Tissue Comment Organism Textmining
additional information the presence of thrombin induces a significant increase in matrix metalloprotease-9 activity and also increases its mRNA expression in primary astrocytes. Thrombin-induced matrix metalloprotease-9 production is inhibited by the selective inhibitor of protease-activated receptor PAR-1, SCH 79797 and by PDS98059 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the presence of thrombin induces a significant increase in matrix metalloprotease-9 activity and also increases its mRNA expression in primary astrocytes. Thrombin-induced matrix metalloprotease-9 production is inhibited by the selective inhibitor of protease-activated receptor PAR-1, SCH 79797 and by PDS98059 Rattus norvegicus ?
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 ?