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Literature summary for 3.4.21.5 extracted from

  • Rahgozar, S.; Giannakopoulos, B.; Yan, X.; Wei, J.; Cheng Qi, J.; Gemmell, R.; Krilis, S.A.
    beta2-Glycoprotein I protects thrombin from inhibition by heparin cofactor II: potentiation of this effect in the presence of anti-beta2-glycoprotein I autoantibodies (2008), Arthritis Rheum., 58, 1146-1155.
    View publication on PubMed

Application

Application Comment Organism
medicine beta2-glycoprotein I may regulate thrombin inactivation by heparin cofactor II. The presence of anti-beta2-glycoprotein I antibodies potentiates the protective effect of beta2-glycoprotein I on thrombin and may explain the prothrombic tendency in patients with antiphospholipid syndrome Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
heparin cofactor II presence of beta2-glycoprotein I protects thrombin against inactivation by heparin cofactor II. Cleavage of beta2-glycoprotein I at residues K317-T318 abrogates its protective effect Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
commercial product
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