Literature summary for 3.4.21.5 extracted from

Croy, C.H.; Koeppe, J.R.; Bergqvist, S.; Komives, E.A.
Allosteric changes in solvent accessibility observed in thrombin upon active site occupation (2004), Biochemistry, 43, 5246-5255.

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Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-
Homo sapiens	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
selective cleavage of Arg-/-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B	two active site loops, residues 214-222 and residues 126-132, undergo decreases in solvent accessibility due to steric contacts with substrate. Two regions outside the active site undergo solvent protection upon substrate binding	Homo sapiens	a
selective cleavage of Arg-/-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B	two active site loops, residues 214-222 and residues 126-132, undergo decreases in solvent accessibility due to steric contacts with substrate. Two regions outside the active site undergo solvent protection upon substrate binding	Bos taurus	a

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Release 2023.1 (January 2023)