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Literature summary for 3.4.21.5 extracted from

  • Chambers, R.C.; Leoni, P.; Blanc-Brude, O.P.; Wembridge, D.E.; Laurent, G.J.
    Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1 (2000), J. Biol. Chem., 275, 35584-35591.
    View publication on PubMed
Search for more literature for 3.4.21.5

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by cycloheximide Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme exerts pro-inflammatory and profibrotic effects via proteolytic activation of the major thrombin receptor ?
-
 ?
protease-activated receptor-1 + H2O Homo sapiens i.e. PAR-1, activation, major thrombin receptor activated PAR-1 product induces connective tissue growth factor production, a fibroblast mitogen, which promotes extracellular matrix protein production ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme exerts pro-inflammatory and profibrotic effects via proteolytic activation of the major thrombin receptor Homo sapiens ?
-
 ?
protease-activated receptor-1 + H2O i.e. PAR-1, activation, major thrombin receptor Homo sapiens activated PAR-1
-
 ?
protease-activated receptor-1 + H2O i.e. PAR-1, activation, major thrombin receptor Homo sapiens activated PAR-1 product induces connective tissue growth factor production, a fibroblast mitogen, which promotes extracellular matrix protein production ?