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Literature summary for 3.4.21.5 extracted from

  • Deinum, J.; Gustavsson, L.; Gyzander, E.; Kullman-Magnusson, M.; Edstroem, A.; Karlsson, R.
    A thermodynamic characterization of the binding of thrombin inhibitors to human thrombin, combining biosensor technology, stopped-Flow spectrophotometry, and microcalorimetry (2002), Anal. Biochem., 300, 152-162.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
CH-248 i.e. (R)-cyclohexylalanyl-Pro-Arg[CH2OCH2CF3] Homo sapiens
inogatran i.e. carboxymethyl-(R)-cyclohexylalanyl-L-piperidine-2-carboxylic acid noragmatine Homo sapiens
melagatran i.e. carboxymethyl-(R)-cyclohexylglycine-L-azetidine-2-carboxylic acid 4-amidinobenzylamine Homo sapiens
additional information inhibitor binding mechanism and kinetics Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-phenylalanyl-pipecolyl-L-arginine-4-nitroanilide + H2O i.e. S2238, synthetic chromogenic substrate Homo sapiens D-phenylalanyl-pipecolyl-L-arginine + 4-nitroaniline
-
?

Synonyms

Synonyms Comment Organism
alpha-thrombin
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information kinetics at 25°C and 37°C, thermodynamic analysis of inhibitor binding and interaction Homo sapiens
0.0000013
-
melagatran pH 7.4, 25°C Homo sapiens
0.000003
-
CH-248 pH 7.4, 25°C Homo sapiens
0.0000043
-
inogatran pH 7.4, 25°C Homo sapiens