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Literature summary for 3.4.21.47 extracted from

  • Rooijakkers, S.H.; Wu, J.; Ruyken, M.; van Domselaar, R.; Planken, K.L.; Tzekou, A.; Ricklin, D.; Lambris, J.D.; Janssen, B.J.; van Strijp, J.A.; Gros, P.
    Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor (2009), Nat. Immunol., 10, 721-727.
    View publication on PubMedView publication on EuropePMC
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Crystallization (Commentary)

Crystallization (Comment) Organism
C3 convertase formed by C3b and the protease fragment Bb in complex with staphylococcal complement inhibitor, hanging drop vapor diffusion method, using 75 mM sodium/potassium tartrate, 8.0% (w/v) PEG 3350, 50 mM Bis-Tris propane, pH 6.5 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
staphylococcal complement inhibitor from Staphylococcus aureus, binds and blocks active convertases in solution and induced dimerization of C3bBb Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
magnetic cobalt beads chromatography and analytical ultracentrifugation Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3 + H2O
-
 Homo sapiens complement component C3a + complement component C3b
-
 ?

Synonyms

Synonyms Comment Organism
alternative complement pathway C3 convertase
-
 Homo sapiens
C3bBb
-
 Homo sapiens