Activating Compound | Comment | Organism | Structure |
---|---|---|---|
factor B | generation of the AP C3-convertase initiates by the binding of factor B to C3b to form the proconvertase, C3bB. Factor B undergoes a dramatic conformational change upon binding to C3b, it binds near the C345C domain in C3b. Factor B-D279G mutant promotes high-affinity C3b-binding and is correctly cleaved by factor D in the C3bB proenzyme to generate a very stable, functionally-active, AP C3-convertase C3bBb | Homo sapiens | |
factor D | the proconvertase C3bB is cleaved by factor D at a single site in factor B, producing Ba and Bb fragments. Ba dissociates from the complex, while Bb remains bound to C3b, forming the active AP C3-convertase C3bBb | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
complement receptor 1 | CR1, mediates decay acceleration of the C3bBb complex | Homo sapiens | |
decay accelerating factor | DAF, mediates decay acceleration of the C3bBb complex | Homo sapiens | |
factor H | mediates decay acceleration of the C3bBb complex | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ni2+ | promotes a stable C3bB complex | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00751 | - |
- |
Purification (Comment) | Organism |
---|---|
C3bB(Ni2+) complex or C3bBb(factor B-D279G mutant) purified by gel filtration | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
alternative pathway C3-convertase | - |
Homo sapiens |
AP C3-convertase | - |
Homo sapiens |
C3bB complex | - |
Homo sapiens |