Literature summary for 3.4.21.47 extracted from

Wiesmann, C.; Katschke, K.J.; Yin, J.; Helmy, K.Y.; Steffek, M.; Fairbrother, W.J.; McCallum, S.A.; Embuscado, L.; DeForge, L.; Hass, P.E.; van Lookeren Campagne, M.
Structure of C3b in complex with CRIg gives insights into regulation of complement activation (2006), Nature, 444, 217-220.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
structural analysis of complement component C3b in complex with the macrophage-expressed complement receptor CRIg, domain architecture of complement component C3 and the C3b/C3c-CRIg complexes shown, structural similarities between complement components C3b and C3c indicated, comparison between complement components C3b and C3 reveals that complement component C3 stimulation is accompanied by major strucural rearrangements	Homo sapiens

Crystallization (Comment)

Organism

structural analysis of complement component C3b in complex with the macrophage-expressed complement receptor CRIg, domain architecture of complement component C3 and the C3b/C3c-CRIg complexes shown, structural similarities between complement components C3b and C3c indicated, comparison between complement components C3b and C3 reveals that complement component C3 stimulation is accompanied by major strucural rearrangements

Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
CRIg	phagocytic receptor, binds to the beta-chain of complement components C3b and C3c and inhibits the AP C3 and C5 convertases, structure-activity relationship of CRIg mutants indicated	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
complement component C3 + H2O	Homo sapiens	-	complement component C3a + complement component C3b	-	?
complement component C5 + H2O	Homo sapiens	-	complement component C5a + complement component C5b	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P00751	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
serum	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
complement component C3 + H2O	-	Homo sapiens	complement component C3a + complement component C3b	-	?
complement component C3 + H2O	analysis of structure and function of complement component C3b in complex with the macrophage-expressed complement receptor CRIg, CRIg shown as an inhibitor of alternative complement convertases	Homo sapiens	complement component C3a + complement component C3b	-	?
complement component C5 + H2O	-	Homo sapiens	complement component C5a + complement component C5b	-	?

Synonyms

Synonyms	Comment	Organism
C3 convertase	-	Homo sapiens