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Literature summary for 3.4.21.47 extracted from

  • Bexborn, F.; Andersson, P.O.; Chen, H.; Nilsson, B.; Ekdahl, K.N.
    The tick-over theory revisited: Formation and regulation of the soluble alternative complement C3 convertase (C3(H(2)O)Bb) (2008), Mol. Immunol., 45, 2370-2379.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.47

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C3 + H2O Homo sapiens
-
 complement component C3a + complement component C3b
-
 ?
complement component C5 + H2O Homo sapiens
-
 complement component C5a + complement component C5b
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P00751
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 convertase formation and activity shown, Western blot, ELISA and fluorescence resonance energy transfer (FRET) used to study formation of the fluid-phase AP convertases C3(H2O)Bb and C3bBb, regulation by factor H and factor I determined, higher affinity for complement component C3(H2O) than for complement component C3b determined, convertase activity of C3bBb higher than of C3(H2O)Bb, C3(H2O)Bb convertase more resistant to inactivation by factor H and factor I than the C3bBb convertase, 25% of initial activity of complement component C3(H2O)Bb retained at conditions that totally inactivate C3bBb Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3 + H2O
-
 Homo sapiens complement component C3a + complement component C3b
-
 ?
complement component C3 + H2O studies on fluid-phase formation of initial convertase by fluorescence resonance energy transfer (FRET) Homo sapiens complement component C3a + complement component C3b
-
 ?
complement component C5 + H2O
-
 Homo sapiens complement component C5a + complement component C5b
-
 ?

Synonyms

Synonyms Comment Organism
C3 convertase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens