Literature summary for 3.4.21.47 extracted from

Huber-Lang, M.; Sarma, J.V.; Zetoune, F.S.; Rittirsch, D.; Neff, T.A.; McGuire, S.R.; Lambris, J.D.; Warner, R.L.; Flierl, M.A.; Hoesel, L.M.; Gebhard, F.; Younger, J.G.; Drouin, S.M.; Wetsel, R.A.; Ward, P.A.
Generation of C5a in the absence of C3: a new complement activation pathway (2006), Nat. Med., 12, 682-687.

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Protein Variants

Protein Variants	Comment	Organism
additional information	enzyme component C3 deletion mutant. Acute lung inflammatory injury is greatly attenuated in lungs of mutant animals, and C5a levels in broncheolar lavage fluids of mutants greatly reduced in presence of antithrombin III or hirudin, compared to wild-type. Plasma from mutant animals contains threefold higher levels of thrombin activity and higher levels of prothrombin mRNA, prothrombin and thrombin protein in liver of mutants	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	wild-type and enzyme component C3 deletion mutant	-

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Release 2023.1 (January 2023)