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Literature summary for 3.4.21.47 extracted from
- Functional role of the noncatalytic subunit of complement C5 convertase (2000), J. Immunol., 164, 1379-1385.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000036 | - |
complement component C5 | 37°C, enzyme CVFn,Bb | Homo sapiens | |
| 0.00124 | - |
complement component C5 | 37°C, enzyme ZymC3b,Bb, surface-bound C5 convertase formed on zymosan particles | Homo sapiens | |
| 0.014 | - |
complement component C5 | 37°C, enzyme CVFh,Bb | Homo sapiens | |
| 0.024 | - |
complement component C5 | 37°C, enzyme C3b,Bb | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | the C5 convertase is a serine protease that consists of two subunits: a catalytic subunit which is bound in a Mg2+-dependent complex to a noncatalytic subunit | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| complement component C5 + H2O | - |
Homo sapiens | complement component C5a + complement component C5b | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | the C5 convertase is a serine protease that consists of two subunits: a catalytic subunit which is bound in a Mg2+-dependent complex to a noncatalytic subunit. The binding site for c5 resides in the noncatalytic subunit of the enzyme, the affinity for the substrate is solely determined by the noncatalytic subunit and the catalytic efficiency of the enzyme appears to to be influenced by the nature of this subunit | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| C3b,Bb | - |
Homo sapiens |
| CVFh,Bb | - |
Homo sapiens |
| CVFn,Bb | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0038 | - |
complement component C5 | 37°C, enzyme ZymC3b,Bb, surface-bound C5 convertase formed on zymosan particles | Homo sapiens | |
| 0.0071 | - |
complement component C5 | 37°C, enzyme CVFn,Bb | Homo sapiens | |
| 0.011 | - |
complement component C5 | 37°C, enzyme C3b,Bb | Homo sapiens | |
| 0.012 | - |
complement component C5 | 37°C, enzyme CVFh,Bb | Homo sapiens |
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