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Literature summary for 3.4.21.47 extracted from
- The C3 convertase of the alternative pathway of human complement. Enzymic properties of the bimolecular proteinase (1986), Biochem. J., 235, 723-730.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00586 | - |
complement component C3 | 37°C | Homo sapiens | |
| 0.0116 | - |
complement component C3 | 37°C | Homo sapiens | |
| 0.0144 | - |
complement component C3 | 30°C | Homo sapiens | |
| 0.0176 | - |
complement component C3 | 20°C | Homo sapiens | |
| 0.0264 | - |
complement component C3 | 10°C | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme is involved in the alternative pathway of human complement | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | association of factor B with C3b in the presence of Mg2+ results in the formation of a bimolecular zymogen C3b,B, which is activated by the serine proteinase factor D, generating the C3 convertase, C3b,Bb | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| complement component C3 + H2O | - |
Homo sapiens | complement component C3a + complement component C3b | - |
? | |
| additional information | the enzyme is involved in the alternative pathway of human complement | Homo sapiens | ? | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
t1/2 = 90 s | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.107 | - |
complement component C3 | 10°C | Homo sapiens | |
| 0.202 | - |
complement component C3 | 20°C | Homo sapiens | |
| 0.367 | - |
complement component C3 | 30°C | Homo sapiens | |
| 0.472 | - |
complement component C3 | 37°C | Homo sapiens | |
| 1.78 | - |
complement component C3 | 37°C | Homo sapiens |
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