Literature summary for 3.4.21.46 extracted from

Karki, R.G.; Powers, J.; Mainolfi, N.; Anderson, K.; Belanger, D.B.; Liu, D.; Ji, N.; Jendza, K.; Gelin, C.F.; Mac Sweeney, A.; Solovay, C.; Delgado, O.; Crowley, M.; Liao, S.M.; Argikar, U.A.; Flohr, S.; La Bonte, L.R.; Lorthiois, E.L.; Vulpetti, A.; Brown, A.; Long, D.; Prentiss, M.; Gradoux, N.; de Erkenez, A.; Cumin, F.; Adams, C.; Jaffe, B.; Mogi, M.
Design, synthesis, and preclinical characterization of selective factor D inhibitors targeting the alternative complement pathway (2019), J. Med. Chem., 62, 4656-4668 .

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Homo sapiens

Crystallization (Comment)	Organism
in complex with inhibitors, sitting drop vapor diffusion method, using 25% (w/v) PEGME 3350, 100 mM Bis-Tris pH 5.5 or 30% (w/v) PEG MME 2000, 0.1 M thiocyanate	Homo sapiens

Inhibitors	Comment	Organism	Structure
3'-(aminomethyl)-N-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl][1,1'-biphenyl]-3-carboxamide	-	Homo sapiens
[2-([3'-[(1S)-1-amino-2-hydroxyethyl][1,1'-biphenyl]-3-yl]methoxy)phenyl]acetic acid	selective inhibitor	Homo sapiens

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
complement factor B + H2O	Homo sapiens	-	?	-	?

Organism	UniProt	Comment	Textmining
Homo sapiens	P00746	-	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
complement factor B + H2O	-	Homo sapiens	?	-	?

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000012	-	pH and temperature not specified in the publication	Homo sapiens	[2-([3'-[(1S)-1-amino-2-hydroxyethyl][1,1'-biphenyl]-3-yl]methoxy)phenyl]acetic acid
0.037	-	pH and temperature not specified in the publication	Homo sapiens	3'-(aminomethyl)-N-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl][1,1'-biphenyl]-3-carboxamide