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Literature summary for 3.4.21.46 extracted from

  • Godahewa, G.I.; Perera, N.C.; Bathige, S.D.; Nam, B.H.; Noh, J.K.; Lee, J.
    Complement factor D homolog involved in the alternative complement pathway of rock bream (Oplegnathus fasciatus) Molecular and functional characterization and immune responsive mRNA expression analysis (2016), Fish Shellfish Immunol., 55, 423-433 .
    View publication on PubMed
Search for more literature for 3.4.21.46

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Oplegnathus fasciatus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement factor B + H2O Oplegnathus fasciatus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Oplegnathus fasciatus
-
 rock bream
-

Purification (Commentary)

Purification (Comment) Organism
amylose resin column chromatography Oplegnathus fasciatus

Source Tissue

Source Tissue Comment Organism Textmining
gill moderate expression Oplegnathus fasciatus
-
heart moderate expression Oplegnathus fasciatus
-
intestine moderate expression Oplegnathus fasciatus
-
kidney moderate expression Oplegnathus fasciatus
-
liver high expression Oplegnathus fasciatus
-
muscle marginal expression Oplegnathus fasciatus
-
spleen predominant expression Oplegnathus fasciatus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement factor B + H2O
-
 Oplegnathus fasciatus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 30000, SDS-PAGE Oplegnathus fasciatus

Synonyms

Synonyms Comment Organism
CFD
-
 Oplegnathus fasciatus

pI Value

Organism Comment pI Value Maximum pI Value
Oplegnathus fasciatus calculated from amino acid sequence
-
 5.5

Expression

Organism Comment Expression
Oplegnathus fasciatus the enzyme is immunologically upregulated by lipopolysaccharide (12 h post injection), Streptococcus iniae (12 h post infection), rock bream iridovirus (6-12 h post infection), and poly I:C (6 h post injection) in spleen tissue up

General Information

General Information Comment Organism
physiological function the enzyme is involved in immune responses in rock bream. The enzyme is vital to alternative complement pathway activation in cleaving complement factor B. This catalytic reaction forms the alternative C3 convertase that is crucial for complement-mediated pathogenesis Oplegnathus fasciatus