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Literature summary for 3.4.21.46 extracted from

  • Ezure, T.; Sugahara, M.; Amano, S.
    Senescent dermal fibroblasts negatively influence fibroblast extracellular matrix-related gene expression partly via secretion of complement factor D (2019), Biofactors, 45, 556-562 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens P00746
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-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
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 Homo sapiens
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skin
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
CFD
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme gene and protein expression are increased in the dermal layer of skin specimens from aged subjects (more than70 years old), compared to young subjects (younger than 20 years old) up

General Information

General Information Comment Organism
malfunction knockdown of complement factor D in senescent fibroblasts significantly reduces the increase of matrix metalloproteinase 1 in the co-cultured young fibroblasts Homo sapiens
physiological function treatment of young fibroblasts with complement factor D results in increased matrix metalloproteinase 1 gene expression Homo sapiens