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Literature summary for 3.4.21.46 extracted from

  • Cresci, G.A.; Allende, D.; McMullen, M.R.; Nagy, L.E.
    Alternative complement pathway component Factor D contributes to efficient clearance of tissue debris following acute CCl4-induced injury (2015), Mol. Immunol., 64, 9-17.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.46

Organism

Organism UniProt Comment Textmining
Mus musculus
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Mus musculus C57BL/6
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
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 Mus musculus
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liver
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 Mus musculus
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Synonyms

Synonyms Comment Organism
alternative complement pathway component Factor D
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 Mus musculus
factor D
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 Mus musculus

General Information

General Information Comment Organism
malfunction deficiency of factor D leads to exacerbated liver injury and inflammatory cells. The absence of Factor D and lack of C3b/iC3b/C3c deposition following CCl4-induced injury is associated with more severe and prolonged liver injury Mus musculus
physiological function alternative complement pathway component Factor D contributes to efficient clearance of tissue debris following acute CCl4-induced injury in the liver. Acute toxic injury to the liver results in the death of hepatocytesby necrosis and apoptosis. If removal of damaged tissue is inadequate and injury persists, reorganization of the extracellular matrix is impaired Mus musculus