Literature summary for 3.4.21.46 extracted from

Degn, SE.; Jensenius, J.C.; Thiel, S.
The pro-Factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function (2014), J. Immunol., 192, 5448-5449.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

General Information

General Information	Comment	Organism
metabolism	in humans neither MASP-1 nor MASP-3 are required for alternative pathway function. During MASP-1/-3 deficiency significant alternative pathway activity remains, indicating that mature factor D is present in the absence of MASP-1/-3	Mus musculus
additional information	influence of buffer composition on the activity of the alternative pathway of complement activation in mice in the presence and the absence of the Masp1 gene products, overview	Mus musculus
physiological function	mature factor D is required for the alternative complement pathway	Mus musculus

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Release 2023.1 (January 2023)