Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.46 extracted from

  • Forneris, F.; Ricklin, D.; Wu, J.; Tzekou, A.; Wallace, R.; Lambris, J.; Gros, P.
    Structures of C3b in complex with factors B and D give insight into complement convertase formation (2010), Science, 330, 1816-1820.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.46

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK293-E cells Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
S183A mutant protein in complex with pro-convertase C3bB Homo sapiens

Protein Variants

Protein Variants Comment Organism
H133A catalytically inactive Homo sapiens
R115C activity like wild type Homo sapiens
R157A catalytically inactive Homo sapiens
R202A putative interaction with Glu230 in factor B, cleavage of factor B reduced to 20%, activity against peptides threefold increased Homo sapiens
S183A catalytically inactive Homo sapiens
V203D very low activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
cation-exchange chromatography,gelfiltration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-Lys-Arg-4-nitroanilide + H2O
-
 Homo sapiens Ac-Lys-Arg + 4-nitroaniline
-
 ?
pro-convertase C3bB + H2O
-
 Homo sapiens active C3 convertase C3bBb + ?
-
 ?

Synonyms

Synonyms Comment Organism
factor D complement Homo sapiens