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Literature summary for 3.4.21.46 extracted from

  • Kinnunen, K.; Kalesnykas, G.; Maehoenen, A.J.; Laidinen, S.; Holma, L.; Heikura, T.; Airenne, K.; Uusitalo, H.; Ylae-Herttuala, S.
    Baculovirus is an efficient vector for the transduction of the eye: comparison of baculovirus- and adenovirus-mediated intravitreal vascular endothelial growth factor D gene transfer in the rabbit eye (2009), J. Gene Med., 11, 382-389.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information adenovirus-mediated expression of VEGF-D is significantly higher than that of baculovirus Homo sapiens

Application

Application Comment Organism
medicine intravitreal VEGF-D gene transfer causes blood-retina barrier breakdown but not neovessel formation in the rabbit eye. Inflammation-like alterations in the choriocapillaries are observed in the baculoviral VEGF-D-treated eyes, but not in adenoviral VEGF-D-treated eyes at 6 days after gene transfer Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
baculoviral VEGF-D or adenoviral VEGF-D expressed in the rabbit eye. VEGF-D expression shows a similar pattern in the retina and retinal pigment epithelium layer after baculoviral and adenoviral transduction. At 6 days after gene transfer, both viruses show dose-dependent increase in the expression of human VEGF-D in the vitreous humour Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
vascular endothelial growth factor D
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Homo sapiens
VEGF-D
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Homo sapiens