C25A |
has increased activity compared to the native VEGF-DDELTANDELTAC. Efficiently binds to the soluble receptor VEGFR-2/IgGFc. The C25A mutant behaves mainly as a monomeric protein on SDS-PAGE under reducing conditions but as a dimeric protein under non-reducing conditions. It induces VEGFR-2 Tyr-1175 phosphorylation |
Homo sapiens |
C25A/P43S |
has biological activity comparable to that of the native protein in Ba/F3-VEGFR-2 cells |
Homo sapiens |
C25I |
is mainly in a presumably covalently bound dimeric form |
Homo sapiens |
C25L |
has increased activity compared to the native VEGF-DDELTANDELTAC, the C25L mutant is the most active mutant and is mainly in a presumably covalently bound dimeric form, has highest affinity to bind soluble receptor VEGFR-2/IgGFc. It induces VEGFR-2 Tyr-1175 phosphorylation |
Homo sapiens |
C25V |
is mainly in a presumably covalently bound dimeric form |
Homo sapiens |
C44A |
does not bind to the soluble receptor VEGFR-2/IgGFc |
Homo sapiens |
C53A |
does not bind the soluble receptors VEGFR-2/IgGFc and VEGFR-3/IgGFc |
Homo sapiens |
C53A |
does not bind to the soluble receptor VEGFR-2/IgGFc |
Homo sapiens |
G51C |
can not induce cell survival, has increased dimer to monomer ratio |
Homo sapiens |
P43S |
can not induce cell survival |
Homo sapiens |
R22I |
can not induce cell survival |
Homo sapiens |
R22I/C25L |
has biological activity comparable to that of the native protein in Ba/F3-VEGFR-2 cells, has increased dimer to monomer ratio |
Homo sapiens |
R22L |
can not induce cell survival |
Homo sapiens |
R22L/C25L |
has biological activity comparable to that of the native protein in Ba/F3-VEGFR-2 cells, has increased dimer to monomer ratio |
Homo sapiens |