Literature summary for 3.4.21.46 extracted from

Schaefer, G.; Wissmann, C.; Hertel, J.; Lunyak, V.; Hoecker, M.
Regulation of vascular endothelial growth factor D by orphan receptors hepatocyte nuclear factor-4 alpha and chicken ovalbumin upstream promoter transcription factors 1 and 2 (2008), Cancer Res., 68, 457-466.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	A direct repeat element located in the proximal human vegf-D gene promoter, consisting of a consensus half-site (AGGTCA) at -125/-119 and a degenerated direct repeat half-site (ATGTTA) at -99/-94 is sufficient and necessary for vegf-D transcription. The vegf-D direct repeat element is bound and activated by the orphan receptors hepatocyte nuclear factor 4A and chicken ovalbumin upstream promoter transcription factor 1 and 2 as well as transcriptional coactivators glucocorticoid receptor interacting protein 1 and cyclic AMP-responsive element binding protein-binding protein to drive vegf-D gene transcription. Histone deacetylase inhibition by trichostatin A leads to accumulation of acetylated histones H3/H4 at the vegf-D promoter, up-regulation of vegf-D mRNA levels, and transactivation of vegf-D promoter reporter gene constructs in cancer cell lines	Homo sapiens

Application

Application	Comment	Organism
medicine	is linked to the control of lymphangiogenesis and lymphatic metastasis. Epigenetic control of histone acetylation represents an important determinant of vegf-D gene expression in cancer cells	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
gastric cells transiently transfected with the pGL3-based vegf-D reporter gene construct vegf-D(-2011/+110), which comprises nucleotides -2011/+110 of the human vegf-D gene	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
AGS cell	low levels of vegf-D mRNA	Homo sapiens	-
gastric cell line	-	Homo sapiens	-
KATO-III cell	low levels of vegf-D mRNA	Homo sapiens	-
MKN-28 cell	low levels of vegf-D mRNA	Homo sapiens	-
MKN-45 cell	5- to 8fold higher amounts of vegf-D mRNA as the other gastric cell lines	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
vascular endothelial growth factor D	-	Homo sapiens
VEGF-D	-	Homo sapiens

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Release 2023.1 (January 2023)