Crystallization (Comment) | Organism |
---|---|
wild type and mutant factor D, expression in CHO cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S94Y | 6fold increase in turnover number | Homo sapiens |
S94Y/T214/S215W | the triple mutant has a turnover number that is 16fold higher than that of wild type factor D | Homo sapiens |
T214S/S215W | more than 16fold incerease of the ratio of turnover number/KM-value | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.95 | - |
Benzyloxycarbonyl-Lys-thiobenzyl ester | mutant enzyme S94Y/T214S/S215W | Homo sapiens | |
3.3 | - |
Benzyloxycarbonyl-Lys-thiobenzyl ester | mutant enzyme S94Y/T214S | Homo sapiens | |
3.79 | - |
Benzyloxycarbonyl-Lys-thiobenzyl ester | wild-type enzyme | Homo sapiens | |
4.72 | - |
Benzyloxycarbonyl-Lys-thiobenzyl ester | mutant enzyme S94Y/S214W | Homo sapiens | |
5.15 | - |
Benzyloxycarbonyl-Lys-thiobenzyl ester | mutant enzyme S94Y | Homo sapiens | |
5.64 | - |
Benzyloxycarbonyl-Lys-thiobenzyl ester | mutant enzyme T214S | Homo sapiens | |
6.37 | - |
Benzyloxycarbonyl-Lys-thiobenzyl ester | mutant enzyme T214S/S215W | Homo sapiens | |
11.44 | - |
Benzyloxycarbonyl-Lys-thiobenzyl ester | mutant enzyme S215W | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-Lys thiobenzyl ester + H2O | - |
Homo sapiens | benzyloxycarbonyl-Lys + phenylmethanethiol | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.3 | - |
Benzyloxycarbonyl-Lys-thiobenzyl ester | wild-type enzyme | Homo sapiens | |
1.84 | - |
Benzyloxycarbonyl-Lys-thiobenzyl ester | mutant enzyme T214S | Homo sapiens | |
4.5 | - |
Benzyloxycarbonyl-Lys-thiobenzyl ester | mutant enzyme S215W | Homo sapiens | |
6.31 | - |
Benzyloxycarbonyl-Lys-thiobenzyl ester | mutant enzyme S94Y/S214W | Homo sapiens | |
7.06 | - |
Benzyloxycarbonyl-Lys-thiobenzyl ester | mutant enzyme T214S/S215W | Homo sapiens | |
7.45 | - |
Benzyloxycarbonyl-Lys-thiobenzyl ester | mutant enzyme S94Y | Homo sapiens | |
12 | - |
Benzyloxycarbonyl-Lys-thiobenzyl ester | mutant enzyme S94Y/T214S | Homo sapiens | |
21.3 | - |
Benzyloxycarbonyl-Lys-thiobenzyl ester | mutant enzyme S94Y/T214S/S215W | Homo sapiens |