Application | Comment | Organism |
---|---|---|
medicine | the serine protease domain of pig factor I indicates that the serine protease functions not only in pig serum, but in human and other serum, as well. Therefore, pig factor I may be considered a substitute for human factor I for the function of serine protease during the treatment of hepatic failure | Sus scrofa |
Cloned (Comment) | Organism |
---|---|
serine protease region of factor I flanked by the Xho I site and cloned into vector pCXN2L/FLAG-PI. Plasmid transformed into Escherichia coli C600 and amplified. Expression in CHO cells | Sus scrofa |
serine protease region of factor I flanked by the Xho I site and cloned into vector pCXN2L/FLAG-PI. Plasmid transformed into Escherichia coli C600 and amplified. Expression in CHO cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | surface-bound form of the serine protease domain | Sus scrofa | 16020 | - |
membrane | surface-bound form of the serine protease domain | Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P05156 | - |
- |
Sus scrofa | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | N-glycosylation sites are Asn-73, 421, 493 and 535, and a O-glycosylation sites is Thr-36. Has little species-specificity like human factor I, according to the relatively high homology of the AA sequences in the serine protease region, in comparison with those of membrane complement regulatory proteins | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Sus scrofa | - |
plasma | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | can be expressed on xenogeneic cell membranes | Sus scrofa | ? | - |
? | |
additional information | human factor I has little species-specificity like pig factor I, according to the relatively high homology of the AA sequences in the serine protease region, in comparison with those of membrane complement regulatory proteins | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
factor I | - |
Sus scrofa |
factor I | - |
Homo sapiens |