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Literature summary for 3.4.21.43 extracted from

  • Kerr, M.A.
    The human complement system: assembly of the classical pathway C3 convertase (1980), Biochem. J., 189, 173-181.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.43

Activating Compound

Activating Compound Comment Organism Structure
complement component C2b essential for the interaction of C4b and C2a Homo sapiens

General Stability

General Stability Organism
complex C4bC2a extremely unstable Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
diisopropyl fluorophosphate
-
 Homo sapiens
EDTA inhibits interaction between C4b and C2b Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ formation of the bimolecular complex C4b2a, i.e. C3 convertase Homo sapiens
Iodine stabilization Homo sapiens
Mg2+ formation of the bimolecular complex C4b2a, i.e. C3 convertase Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
305000
-
 calculation from sedimentation coefficient and diffusion constant Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
37
-
 decay rate constant k: 2.0 per min Homo sapiens