General Stability | Organism |
---|---|
complement component C2b accelerates dissociation | Homo sapiens |
complex C4bC2a extremely unstable | Homo sapiens |
dilute iodine solution stabilizes | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iodine | stabilization | Homo sapiens | |
Mg2+ | formation of the bimolecular complex C4b2a, i.e. C3 convertase | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
280000 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C3 + H2O | Homo sapiens | classical pathway of the complement system | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
2 distinct C3 convertases generated by 2 seperate enzyme cascade systems | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
Selective cleavage of Arg-/-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-/- bond in complement component C5 alpha-chain to form C5a and C5b | hydrolyses peptide bond 77 (Arg-Ser) in complement component C3, and complement component C5. Cleavage of C5 requires complement fragment C3b which binds C5 and renders it susceptible to cleavage by the C4b,C2a complex | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
Storage Stability | Organism |
---|---|
0°C, 8 d, 40% loss of activity | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C3 + H2O | hydrolyzes peptide bond Arg77-Ser of the alpha-chain of C3 | Homo sapiens | complement component C3a + complement component C3b | - |
? | |
complement component C3 + H2O | classical pathway of the complement system | Homo sapiens | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
24 | - |
half-life: 400 min | Homo sapiens |
30 | - |
half-life: 180 min | Homo sapiens |
37 | - |
half-life: 60 min | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Homo sapiens |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
6.5 | 9 | at pH 6.5 more stable than at pH 9 | Homo sapiens |