Literature summary for 3.4.21.43 extracted from

Laursen, N.; Andersen, K.; Braren, I.; Spillner, E.; Sottrup-Jensen, L.; Andersen, G.
Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex (2011), EMBO J., 30, 606-616.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structures of the C3b homologue cobra venom factor CVF in complex with C5, and in complex with C5 and the inhibitor SSL7, both at 4.3 A resolution. The structures reveal a parallel two-point attachment between C5 and CVF, where the presence of SSL7 only slightly affects the C5-CVF interface, explaining the IgA dependence for SSL7-mediated inhibition of C5 cleavage. CVF functions as a relatively rigid binding scaffold inducing a conformational change in C5, which positions its cleavage site in proximity to the serine protease Bb	Homo sapiens

Crystallization (Comment)

Organism

crystal structures of the C3b homologue cobra venom factor CVF in complex with C5, and in complex with C5 and the inhibitor SSL7, both at 4.3 A resolution. The structures reveal a parallel two-point attachment between C5 and CVF, where the presence of SSL7 only slightly affects the C5-CVF interface, explaining the IgA dependence for SSL7-mediated inhibition of C5 cleavage. CVF functions as a relatively rigid binding scaffold inducing a conformational change in C5, which positions its cleavage site in proximity to the serine protease Bb

Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P01031	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

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Release 2023.1 (January 2023)