Inhibitors | Comment | Organism | Structure |
---|---|---|---|
C4b-binding protein | regulates assembly and decay of the classical pathway C3/C5 convertase 4times lower than the lectin pathway convertase | Ovis aries |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Ovis aries | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C3 + H2O | - |
Ovis aries | complement component C3a + complement component C3b | - |
? | |
complement component C5 + H2O | - |
Ovis aries | complement component C5a + complement component C5b | - |
? |
Synonyms | Comment | Organism |
---|---|---|
classical pathway C3/C5 convertase | - |
Ovis aries |
high affinity C5 convertase | EAC1,C3bC4b,C2a | Ovis aries |
soluble C3 convertase | C4b,C2a | Ovis aries |
surface-bound C3 convertase | EAC1,C4b,C2a | Ovis aries |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000005 | - |
IC50 for the inhibition of formation of soluble C3 convertase (C4b,C2a) | Ovis aries | C4b-binding protein | |
0.000011 | - |
IC50 for the acceleration of decay of surface-bound C3 convertase (EAC1,C4b,C2a) | Ovis aries | C4b-binding protein | |
0.000017 | - |
IC50 for the acceleration of decay of soluble C3 convertase (C4b,C2a) | Ovis aries | C4b-binding protein | |
0.00002 | - |
IC50 for the acceleration of decay of high affinity C5 convertase (EAC1,C3bC4b,C2a) | Ovis aries | C4b-binding protein | |
0.000035 | - |
IC50 for the inhibition of formation of surface-bound C3 convertase (EAC1,C4b,C2a) | Ovis aries | C4b-binding protein | |
0.000072 | - |
IC50 for the inhibition of formation of high affinity C5 convertase (EAC1,C3bC4b,C2a) | Ovis aries | C4b-binding protein |