Literature summary for 3.4.21.43 extracted from

Leinhase, I.; Schmidt, O.I.; Thurman, J.M.; Hossini, A.M.; Rozanski, M.; Taha, M.E.; Scheffler, A.; John, T.; Smith, W.R.; Holers, V.M.; Stahel, P.F.
Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury (2006), Exp. Neurol., 199, 454-464.

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Application

Application	Comment	Organism
pharmacology	pharmacological complement inhibition at the C3 convertase level is a promising approach for attenuation of neuroinflammation and secondary neurodegeneration after head injury	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
complement receptor type 1-related protein y	i.e. Crry, a mouse-specific complement inhibitor, expressed in astrocytes, microglia, and neurons of murine brain, in vivo and in vitro inhibition of C3 convertase, overview	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
hippocampus	-	Mus musculus	-
neuron	pyramidal neurons	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury, overview	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
C3 convertase	-	Mus musculus

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Release 2023.1 (January 2023)