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Literature summary for 3.4.21.4 extracted from

  • Sha, H.; Ma, Q.; Jha, R.K.
    Trypsin is the culprit of multiple organ injury with severe acute pancreatitis (2009), Med. Hypotheses, 72, 180-182.
    View publication on PubMed

Application

Application Comment Organism
medicine trypsin is the chief culprit of severe acute pancreatitis-associated multiple organ dysfunction syndromes, the pancreatic tissue bleeding and necrosis is special pathological change in pancreas autodigestive effect from digestive enzymes such as trypsin in severe acute pancreatitis, the activated trypsin destroys the pancreas itself causing pancreatic tissue bleeding and necrosis, trypsin also destroys the vascular endothelial barrier leading to highly increased vascular permeability Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fibronectin + H2O
-
Rattus norvegicus ?
-
?