Literature summary for 3.4.21.39 extracted from

Waern, I.; Lundequist, A.; Pejler, G.; Wernersson, S.
Mast cell chymase modulates IL-33 levels and controls allergic sensitization in dust-mite induced airway inflammation (2013), Mucosal Immunol., 6, 911-920.

Search for more literature for 3.4.21.39

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
interleukin-33 + H2O	Mus musculus	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P21812	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
mast cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
interleukin-33 + H2O	-	Mus musculus	?	-	?
succinyl-L-Ala-L-Ala-L-Pro-L-Phe-7-amido-4-methylcoumarin + H2O	-	Mus musculus	succinyl-L-Ala-L-Ala-L-Pro-L-Phe + 7-amino-4-methylcoumarin	-	?

Synonyms

Synonyms	Comment	Organism
mast cell protease 4	-	Mus musculus
MCP-4	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	MCP-4-defeicient mice demonstrate elevated airway reactivity and eosinophilia in allergic airway inflammation induced by house-dust mite compared with wild type animals. The elevated airway and inflammatory responses of mMCP-4-deficient mice are associated with a profound increase in the levels of interleukin-33 in the lung tissue	Mus musculus
physiological function	mast cell chymase plays a protective role in airway inflammation by regulation of interleukin-33	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)