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Literature summary for 3.4.21.39 extracted from

  • Takai, S.; Jin, D.; Miyazaki, M.
    Multiple mechanisms for the action of chymase inhibitors (2012), J. Pharmacol. Sci., 118, 311-316.
    View publication on PubMed
Search for more literature for 3.4.21.39

Application

Application Comment Organism
medicine chymase inhibitors have no blood pressure-lowering effect despite blocking angiotensin II formation. Thus, chymase inhibitors may be useful for preventing damage to various organs via multiple mechanisms without lowering blood pressure. Chymase inhibitors may be widely used for prevention of angiotensin II- and inflammation-related diseases Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Homo sapiens
-
 angiotensin II + His-Leu
-
 ?
pro-matrix metalloproteinase-9 + H2O Homo sapiens
-
 matrix metalloproteinase-9 + ?
-
 ?
pro-transforming growth factor-beta + H2O Homo sapiens
-
 transforming growth factor-beta + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P23946
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mast cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Homo sapiens angiotensin II + His-Leu
-
 ?
pro-matrix metalloproteinase-9 + H2O
-
 Homo sapiens matrix metalloproteinase-9 + ?
-
 ?
pro-transforming growth factor-beta + H2O
-
 Homo sapiens transforming growth factor-beta + ?
-
 ?

pH Range

pH Minimum pH Maximum Comment Organism
7 9 the pH range of chymase is between 7 and 9, there is no enzymatic activity at pH 5.5 Homo sapiens

General Information

General Information Comment Organism
physiological function chymase is involved in the progression of diabetes Homo sapiens