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Literature summary for 3.4.21.39 extracted from

  • Roy, A.; Ganesh, G.; Sippola, H.; Bolin, S.; Sawesi, O.; Dagaelv, A.; Schlenner, S.M.; Feyerabend, T.; Rodewald, H.R.; Kjellen, L.; Hellman, L.; Abrink, M.
    Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation (2014), J. Biol. Chem., 289, 237-250.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
chymostatin
-
Homo sapiens
chymostatin
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Homo sapiens
-
angiotensin II + His-Leu
-
?
angiotensin I + H2O Mus musculus
-
angiotensin II + His-Leu
-
?
biglycan + H2O Homo sapiens
-
?
-
?
biglycan + H2O Mus musculus
-
?
-
?
heat shock protein 70 + H2O Homo sapiens
-
?
-
?
heat shock protein 70 + H2O Mus musculus
-
?
-
?
HMGB1 + H2O Homo sapiens
-
?
-
?
HMGB1 + H2O Mus musculus
-
?
-
?
interleukin-33 + H2O Homo sapiens
-
?
-
?
interleukin-33 + H2O Mus musculus
-
?
-
?
additional information Homo sapiens interleukin-7, interleukin-22, GM-CSF, and CCL2 are resistant to chymase degradation ?
-
?
additional information Mus musculus interleukin-7, interleukin-22, GM-CSF, and CCL2 are resistant to chymase degradation ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P23946
-
-
Mus musculus P21812
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA agarose bead chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
mast cell
-
Homo sapiens
-
mast cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
Homo sapiens angiotensin II + His-Leu
-
?
angiotensin I + H2O
-
Mus musculus angiotensin II + His-Leu
-
?
biglycan + H2O
-
Homo sapiens ?
-
?
biglycan + H2O
-
Mus musculus ?
-
?
heat shock protein 70 + H2O
-
Homo sapiens ?
-
?
heat shock protein 70 + H2O
-
Mus musculus ?
-
?
HMGB1 + H2O
-
Homo sapiens ?
-
?
HMGB1 + H2O
-
Mus musculus ?
-
?
interleukin-33 + H2O
-
Homo sapiens ?
-
?
interleukin-33 + H2O
-
Mus musculus ?
-
?
additional information interleukin-7, interleukin-22, GM-CSF, and CCL2 are resistant to chymase degradation Homo sapiens ?
-
?
additional information interleukin-7, interleukin-22, GM-CSF, and CCL2 are resistant to chymase degradation Mus musculus ?
-
?
N-succinyl-L-Leu-L-Leu-L-Val-L-Tyr-4-nitroanilide + H2O
-
Homo sapiens N-succinyl-L-Leu-L-Leu-L-Val-L-Tyr + 4-nitroaniline
-
?
N-succinyl-L-Leu-L-Leu-L-Val-L-Tyr-4-nitroanilide + H2O
-
Mus musculus N-succinyl-L-Leu-L-Leu-L-Val-L-Tyr + 4-nitroaniline
-
?

Synonyms

Synonyms Comment Organism
mast cell chymase
-
Homo sapiens
mast cell chymase
-
Mus musculus
MCPT-4
-
Mus musculus

General Information

General Information Comment Organism
physiological function mast cell chymase degrades alarmins and may limit inflammation Homo sapiens
physiological function mast cell chymase degrades alarmins and may limit inflammation Mus musculus