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Literature summary for 3.4.21.39 extracted from

  • Firth, J.D.; Uitto, V.J.; Putnins, E.E.
    Mechanical induction of an epithelial cell chymase associated with wound edge migration (2008), J. Biol. Chem., 283, 34983-34993.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.39

Activating Compound

Activating Compound Comment Organism Structure
additional information chymase is activated 3fold within 60 min in basal media by scratch wounding cultured monolayers and further potentiated over 10fold at 18 h by additional serum and cytokine treatment, chymase activation is attenuated by inhibition of nitric oxide, superoxide, and peroxynitrite Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
chymostatin
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
 SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
aprotinin-Sepharose affinity column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
 Homo sapiens
-
keratinocyte cutaneous and gingival keratinocytes Homo sapiens
-
NHEK cell
-
 Homo sapiens
-
ovarian surface epithelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fibronectin + H2O
-
 Homo sapiens ?
-
 ?
N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine-p-nitroanilide + H2O
-
 Homo sapiens N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine + p-nitroaniline
-
 ?