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Literature summary for 3.4.21.39 extracted from

  • Miyazaki, M.; Takai, S.; Jin, D.; Muramatsu, M.
    Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models (2006), Pharmacol. Ther., 112, 668-676.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-heptyl] acetamide NK3201 Canis lupus familiaris
2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-heptyl] acetamide NK3201 Homo sapiens
2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-heptyl] acetamide NK3201 Mesocricetus auratus
2-[4-(5-fluoro-3-methylbenzo[b] thiophen-2-yl)sulfonamido-3-methansulfonylphenyl]oxazole-4-carboxylic acid TY-1184 Canis lupus familiaris
2-[4-(5-fluoro-3-methylbenzo[b] thiophen-2-yl)sulfonamido-3-methansulfonylphenyl]oxazole-4-carboxylic acid TY-1184 Homo sapiens
2-[4-(5-fluoro-3-methylbenzo[b] thiophen-2-yl)sulfonamido-3-methansulfonylphenyl]oxazole-4-carboxylic acid TY-1184 Mesocricetus auratus
3[(3-amino-4-carboxy) phenylsulfonyl]-7-chloroquinazolone-2,4(1H,3H)-dione N-C8257 Canis lupus familiaris
3[(3-amino-4-carboxy) phenylsulfonyl]-7-chloroquinazolone-2,4(1H,3H)-dione N-C8257 Homo sapiens
3[(3-amino-4-carboxy) phenylsulfonyl]-7-chloroquinazolone-2,4(1H,3H)-dione N-C8257 Mesocricetus auratus
4-[1-[bis-(4-methyl-phenyl)-methyl]-carbamoyl]-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy-benzoic acid BCEAB Canis lupus familiaris
4-[1-[bis-(4-methyl-phenyl)-methyl]-carbamoyl]-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy-benzoic acid BCEAB Homo sapiens
4-[1-[bis-(4-methyl-phenyl)-methyl]-carbamoyl]-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy-benzoic acid BCEAB Mesocricetus auratus
chymostatin
-
Canis lupus familiaris
chymostatin
-
Homo sapiens
chymostatin
-
Mesocricetus auratus
Suc-Val-Pro-PheP-(OPh)2 noncompetitive inhibitor Canis lupus familiaris
Suc-Val-Pro-PheP-(OPh)2 noncompetitive inhibitor Homo sapiens
Suc-Val-Pro-PheP-(OPh)2 noncompetitive inhibitor Mesocricetus auratus

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Homo sapiens
-
-
-
Mesocricetus auratus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mast cell
-
Homo sapiens
-
mast cell
-
Canis lupus familiaris
-
mast cell
-
Mesocricetus auratus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
Homo sapiens angiotensin II + ?
-
?
angiotensin I + H2O
-
Canis lupus familiaris angiotensin II + ?
-
?
angiotensin I + H2O
-
Mesocricetus auratus angiotensin II + ?
-
?
latent transforming growth factor-beta + H2O
-
Homo sapiens active transforming growth factor-beta + ?
-
?
latent transforming growth factor-beta + H2O
-
Canis lupus familiaris active transforming growth factor-beta + ?
-
?
latent transforming growth factor-beta + H2O
-
Mesocricetus auratus active transforming growth factor-beta + ?
-
?

Synonyms

Synonyms Comment Organism
alpha-chymase
-
Homo sapiens
alpha-chymase
-
Canis lupus familiaris
alpha-chymase
-
Mesocricetus auratus
mast cell protease
-
Homo sapiens
mast cell protease
-
Canis lupus familiaris
mast cell protease
-
Mesocricetus auratus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000028
-
-
Homo sapiens Suc-Val-Pro-PheP-(OPh)2
0.0000054
-
-
Homo sapiens 4-[1-[bis-(4-methyl-phenyl)-methyl]-carbamoyl]-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy-benzoic acid
0.000012
-
-
Canis lupus familiaris 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-heptyl] acetamide
0.000025
-
-
Homo sapiens 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-heptyl] acetamide
0.000037
-
-
Homo sapiens 2-[4-(5-fluoro-3-methylbenzo[b] thiophen-2-yl)sulfonamido-3-methansulfonylphenyl]oxazole-4-carboxylic acid
0.000058
-
-
Canis lupus familiaris 2-[4-(5-fluoro-3-methylbenzo[b] thiophen-2-yl)sulfonamido-3-methansulfonylphenyl]oxazole-4-carboxylic acid
0.000128
-
-
Mesocricetus auratus 2-[4-(5-fluoro-3-methylbenzo[b] thiophen-2-yl)sulfonamido-3-methansulfonylphenyl]oxazole-4-carboxylic acid
0.00028
-
-
Mesocricetus auratus 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-heptyl] acetamide
0.00031
-
-
Homo sapiens 3-[(3-amino-4-carboxy) phenylsulfonyl]-7-chloroquinazolone-2,4(1H,3H)-dione
0.00068
-
-
Mesocricetus auratus 3-[(3-amino-4-carboxy) phenylsulfonyl]-7-chloroquinazolone-2,4(1H,3H)-dione