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Literature summary for 3.4.21.39 extracted from

  • Neumann, U.; Schechter, N.M.; Gutschow, M.
    Inhibition of human chymase by 2-amino-3,1-benzoxazin-4-ones (2001), Bioorg. Med. Chem., 9, 947-954.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-(benzylamino)-4H-3,1-benzoxazin-4-one
-
Homo sapiens
2-(N-benzyl-N-methylamino)-4H-3,1-benzoxazin-4-one inhibitor forms a stable acyl-enzyme with half-life of 53 min Homo sapiens
2-(N-benzyl-N-methylamino)-6-methyl-4H-3,1-benzoxazin-4-one
-
Homo sapiens
2-(N-methyl-N-phenylamino)-4H-3,1-benzoxazin-4-one inhibitor forms a stable acyl-enzyme with half-life of 25 min Homo sapiens
6-methyl-2-(N-methyl-N-phenylamino)-4H-3,1-benzoxazin-4-one
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
-
Homo sapiens succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000005
-
2-(benzylamino)-4H-3,1-benzoxazin-4-one pH 8.0, 25°C Homo sapiens
0.000011
-
2-(N-benzyl-N-methylamino)-4H-3,1-benzoxazin-4-one pH 8.0, 25°C Homo sapiens
0.000014
-
2-(N-methyl-N-phenylamino)-4H-3,1-benzoxazin-4-one pH 8.0, 25°C Homo sapiens
0.000017
-
2-(N-benzyl-N-methylamino)-6-methyl-4H-3,1-benzoxazin-4-one pH 8.0, 25°C Homo sapiens
0.000029
-
6-methyl-2-(N-methyl-N-phenylamino)-4H-3,1-benzoxazin-4-one pH 8.0, 25°C Homo sapiens