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Literature summary for 3.4.21.38 extracted from

  • Konings, J.; Hoving, L.R.; Ariens, R.S.; Hethershaw, E.L.; Ninivaggi, M.; Hardy, L.J.; de Laat, B.; Ten Cate, H.; Philippou, H.; Govers-Riemslag, J.W.
    The role of activated coagulation factor XII in overall clot stability and fibrinolysis (2015), Thromb. Res., 136, 474-480 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor XI + H2O Homo sapiens
-
factor XIa + ?
-
?
plasminogen + H2O Homo sapiens
-
plasmin + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor XI + H2O
-
Homo sapiens factor XIa + ?
-
?
plasminogen + H2O
-
Homo sapiens plasmin + ?
-
?
S-2251 + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 80000, calculated from amino acid sequence Homo sapiens

Synonyms

Synonyms Comment Organism
activated coagulation factor XII
-
Homo sapiens
alpha-FXIIa
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme enhances fibrinolysis in the presence of plasminogen. The enzyme first strengthens the clot structure during clot formation and thereafter contributes towards fibrinolysis Homo sapiens