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Literature summary for 3.4.21.38 extracted from
- Heparan sulfate proteoglycans mediate factor XIIa binding to the cell surface (2015), J. Biol. Chem., 290, 7027-7039 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor XI + H2O | Homo sapiens | - |
factor XIa + ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor XI + H2O | - |
Homo sapiens | factor XIa + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| factor XIIa | - |
Homo sapiens |
| FXII | zymogen | Homo sapiens |
| FXIIa | - |
Homo sapiens |
| Hageman factor | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme utilizes cell membrane-bound glycosaminoglycans to interact with the cell surface of human lung fibroblasts. The enzyme stimulates human lung fibroblast migration during idiopathic pulmonary fibrosis | Homo sapiens |
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Release 2023.1 (January 2023)
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