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Literature summary for 3.4.21.38 extracted from

  • Pham, M.; Stoll, G.; Nieswandt, B.; Bendszus, M.; Kleinschnitz, C.
    Blood coagulation factor XII-a neglected player in stroke pathophysiology (2011), J. Mol. Med., 90, 119-126.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
rHA-infestin-4 serine protease inhibitor isolated from Triatoma infestans Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor XI + H2O Mus musculus
-
factor XIa + ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus P00748
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor XI + H2O
-
Mus musculus factor XIa + ?
-
?

Synonyms

Synonyms Comment Organism
blood coagulation factor XII
-
Mus musculus
blood coagulation factor XII serine protease Mus musculus
FXII
-
Mus musculus

General Information

General Information Comment Organism
malfunction hereditary factor XII deficiency does not induce any bleeding phenotype. FXII deficiency prevents pathological thrombus formation, but does not affect regular hemostasis Mus musculus
physiological function activated by contact with negatively charged surfaces, involved in clot formation Mus musculus
physiological function blood coagulation factor XII initiates the intrinsic pathway of coagulation which, together with the extrinsic pathway, culminates in the formation of fibrin Mus musculus