Application | Comment | Organism |
---|---|---|
drug development | a contact phase inhibitor of FXIIa is an effective and safe antithrombotic agent in vivo | Mus musculus |
drug development | a contact phase inhibitor of FXIIa is an effective and safe antithrombotic agent in vivo | Homo sapiens |
drug development | a contact phase inhibitor of FXIIa is an effective and safe antithrombotic agent in vivo | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ir-CPI | the recombinant Ixodes ricinus contact phase inhibitor, a Kunitz type protein expressed by the salivary glands of the tick Ixodes ricinus, specifically interacts with activated human contact phase factors FXIIa, FXIa, and kallikrein. Ir-CPI inhibits the activation of contact system factors, and it prolongs the activated partial thromboplastin time in vitro. Effects of Ir-CPI in vivo are determined using both venous and arterial thrombosis models, overview | Homo sapiens | |
Ir-CPI | the recombinant Ixodes ricinus contact phase inhibitor, a Kunitz-type protein expressed by the salivary glands of the tick Ixodes ricinus, Ir-CPI inhibits the activation of contact system factors, and it prolongs the activated partial thromboplastin time in vitro. Effects of Ir-CPI in vivo are determined using both venous and arterial thrombosis models, overview. the effective antithrombotic dose of Ir-CPI did not promote bleeding or impair blood coagulation parameters | Mus musculus | |
Ir-CPI | the recombinant Ixodes ricinus contact phase inhibitor, a Kunitz-type protein expressed by the salivary glands of the tick Ixodes ricinus, Ir-CPI inhibits the activation of contact system factors, and it prolongs the activated partial thromboplastin time in vitro. Effects of Ir-CPI in vivo are determined using both venous and arterial thrombosis models, overview. the effective antithrombotic dose of Ir-CPI did not promote bleeding or impair blood coagulation parameters | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Mus musculus | - |
- |
extracellular | - |
Homo sapiens | - |
- |
extracellular | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
prekallikrein + H2O | Mus musculus | - |
kallikrein + kallikrein prepeptide | - |
? | |
prekallikrein + H2O | Homo sapiens | - |
kallikrein + kallikrein prepeptide | - |
? | |
prekallikrein + H2O | Rattus norvegicus | - |
kallikrein + kallikrein prepeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Mus musculus | - |
blood | - |
Homo sapiens | - |
blood | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prekallikrein + H2O | - |
Mus musculus | kallikrein + kallikrein prepeptide | - |
? | |
prekallikrein + H2O | - |
Homo sapiens | kallikrein + kallikrein prepeptide | - |
? | |
prekallikrein + H2O | - |
Rattus norvegicus | kallikrein + kallikrein prepeptide | - |
? | |
prekallikrein + H2O | cleavage of a single peptide bond | Mus musculus | kallikrein + kallikrein prepeptide | - |
? | |
prekallikrein + H2O | cleavage of a single peptide bond | Homo sapiens | kallikrein + kallikrein prepeptide | - |
? | |
prekallikrein + H2O | cleavage of a single peptide bond | Rattus norvegicus | kallikrein + kallikrein prepeptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FXIIa | - |
Mus musculus |
FXIIa | - |
Homo sapiens |
FXIIa | - |
Rattus norvegicus |