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Literature summary for 3.4.21.38 extracted from

  • Schousboe, I.; Nystrom, B.T.; Hansen, G.H.
    Differential binding of factor XII and activated factor XII to soluble and immobilized fibronectin--localization of the Hep-1/Fib-1 binding site for activated factor XII (2008), FEBS J., 275, 5161-5172.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
corn trypsin inhibitor inhibits the activity of FXIIa, and thus the autoactivation of FXII Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular matrix FXIIa, but not FXII, binds to the extracellular matrix Homo sapiens 31012
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
proenzyme FXII, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens FXIIa, but not FXII, binds in a Zn2+-independent manner to immobilized fibronectin, the binding of FXIIa to fibronectin is inhibited by gelatine and fibrin but not by heparin ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell
-
Homo sapiens
-
umbilical vein endothelial cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor XI + H2O
-
Homo sapiens factor XIa + ?
-
?
additional information FXIIa, but not FXII, binds in a Zn2+-independent manner to immobilized fibronectin, the binding of FXIIa to fibronectin is inhibited by gelatine and fibrin but not by heparin Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
factor XII
-
Homo sapiens
FXII FXII is a zymogen of the proteolytically active FXIIa that plays a role in thrombus stabilization by enhancing clot formation and in inflammation by enhancing bradykinin formation Homo sapiens
FXIIa activated factor XII Homo sapiens