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Literature summary for 3.4.21.38 extracted from

  • Schousboe, I.
    Endothelial cells express a matrix protein which binds activated factor XII in a zinc-independent manner (2006), Thromb. Haemost., 95, 312-319.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens roles of enzyme as a modulator of cellular adhesion, migration and vascularization ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification high molecular mass kininogen interferes with the binding of factor XII to sulfatides and its autoactivation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
umbilical vein endothelial cell i.e. HUVEC, confluent layers Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information roles of enzyme as a modulator of cellular adhesion, migration and vascularization Homo sapiens ?
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 ?

Subunits

Subunits Comment Organism
More sulfatides enhance the binding of factor XII to a matrix protein expressed during growth of the endothelial cells. Binding is independent of Zn2+ and specific for alpha-XIIa with a dissociation constant of 12.8 nM Homo sapiens