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Literature summary for 3.4.21.37 extracted from

  • Yang, R.; Zhong, L.; Yang, X.Q.; Jiang, K.L.; Li, L.; Song, H.; Liu, B.Z.
    Neutrophil elastase enhances the proliferation and decreases apoptosis of leukemia cells via activation of PI3K/Akt signaling (2016), Mol. Med. Rep., 13, 4175-4182 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in NB-4 cells and U-937 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Elastin + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 29000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
neutrophil elastase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme enhances the proliferation and decreases apoptosis of leukemia cells via activation of PI3K/Akt signaling. The enzyme significantly promotes the proliferation of NB-4 cells, inhibits cell apoptosis and apoptotic signaling, and leads the activation of Akt. Homo sapiens