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Literature summary for 3.4.21.37 extracted from

  • Tan, X.F.; Kim, D.W.; Song, Y.H.; Kim, J.Y.; Yuk, H.J.; Wang, Y.; Curtis-Long, M.J.; Park, K.H.
    Human neutrophil elastase inhibitory potential of flavonoids from Campylotropis hirtella and their kinetics (2016), J. Enzyme Inhib. Med. Chem., 31, 16-22 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2R, 3R)-6-methyl-3'-geranyl-2,3-trans-5,7,4'-trihydroxyflavonol
-
Homo sapiens
(E)-3-(3-(3,7-dimethylocta-2,6-dienyl)-2,4-dihydroxyphenyl)-3,5,7-trihydroxy-chroman-4-one competitive inhibitor Homo sapiens
3'-geranyl-5,7,2',4'-tetrahydroxyisoflavanone
-
Homo sapiens
additional information not inhibited by dalbergioidin, 3(S)-2',4'-dihydroxy-5,5'-dimethoxy-(6'',6''-dimethylpyano)-(2'',3'':7,6)-isoflavan, myrsininone A, isosophoranone, myrsininone B, and 3'-geranyl-5,7,2',5'-tetrahydroxyisoflavone Homo sapiens
oleanolic acid
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O Homo sapiens
-
methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroanilide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
Homo sapiens methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroanilide
-
?

Synonyms

Synonyms Comment Organism
HNE
-
Homo sapiens
neutrophil elastase
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.01634
-
(E)-3-(3-(3,7-dimethylocta-2,6-dienyl)-2,4-dihydroxyphenyl)-3,5,7-trihydroxy-chroman-4-one at pH 8.0, temperature not specified in the publication Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0085
-
at pH 8.0, temperature not specified in the publication Homo sapiens (E)-3-(3-(3,7-dimethylocta-2,6-dienyl)-2,4-dihydroxyphenyl)-3,5,7-trihydroxy-chroman-4-one
0.0179
-
at pH 8.0, temperature not specified in the publication Homo sapiens (2R, 3R)-6-methyl-3'-geranyl-2,3-trans-5,7,4'-trihydroxyflavonol
0.02168
-
at pH 8.0, temperature not specified in the publication Homo sapiens oleanolic acid
0.0308
-
at pH 8.0, temperature not specified in the publication Homo sapiens 3'-geranyl-5,7,2',4'-tetrahydroxyisoflavanone